sipT [2018-02-08 10:57:14]

signal peptidase I

Locus: BSU14410

Isoelectric point: 9.85

Molecular weight: 21.71 kDa

Protein length: 193 aa

Gene length: 579 bp

Function: protein secretion

Product: signal peptidase I

Essential: no

Synonyms

Genomic Context

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Categories containing this gene/protein

• Information processing → Protein synthesis, modification and degradation → Protein secretion
• Groups of genes → Membrane proteins

Gene

Coordinates: 1,511,308 → 1,511,889

Phenotypes of a mutant

• a sipS sipT double mutant is not viable PubMed

The protein

Catalyzed reaction/ biological activity

• Cleavage of hydrophobic, N-terminal signal or leader sequences from secreted and periplasmic proteins (according to Swiss-Prot)

Protein family

• peptidase S26 family (according to Swiss-Prot)

Paralogous protein(s)

• SipS, SipU, SipV

Structure

• 4NV4 (from B. anthracis, 44% identity)

Localization

• cell membrane (according to Swiss-Prot)

Expression and Regulation

Operons

• Genes: sipT
  Description: PubMed

  Regulatory mechanism

  • DegU: activation, PubMed, in DegU regulon

Biological materials

Mutant

• BKE14410 (ΔsipT::erm trpC2) available at BGSC, PubMed, upstream reverse: _UP1_CAAAGTGTTTCCTCCTAGAC, downstream forward: _UP4_TAAAAACGCCTTGCTGGCCT
• BKK14410 (ΔsipT::kan trpC2) available at BGSC, PubMed, upstream reverse: _UP1_CAAAGTGTTTCCTCCTAGAC, downstream forward: _UP4_TAAAAACGCCTTGCTGGCCT

Labs working on this gene/protein

• Jan Maarten van Dijl, Groningen, Netherlands

References

Reviews

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Original publications

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